development of 177lu-phytate complex for radiosynovectomy

objective(s): in this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. materials and methods: lu-177 of 2.6-3 gbq/mg specific activity was obtained by irradiation of natural lu2o3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. the product was converted into chloride form which was further used for labeling of 177lu-phytate complex and checked using itlc (meoh: h2o: acetic acid, 4: 4: 2, as mobile phase). the complex stability and viscosity were checked in the final solution up to seven days. the prepared complex solution (100 µci/100 µl) was injected intra-articularly to male rat knee joint. leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. results: the complex was successfully prepared with high radiochemical purity (>99.9 %). approximately, the whole injected dose has remained in injection site seven days after injection. conclusion: the complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology